UZH-Logo

Maintenance Infos

Looking beyond the genes: the interplay between signaling pathways and mechanics in the shaping and diversification of epithelial tissues


Urdy, Severine; Goudemand, Nicolas; Pantalacci, Sophie (2016). Looking beyond the genes: the interplay between signaling pathways and mechanics in the shaping and diversification of epithelial tissues. In: Orgogozo, Virginie. Genes and Evolution. Cambridge: Elsevier, 227-290.

Abstract

The core of Evo-Devo lies in the intuition that the way tissues grow during embryonic development, the way they sustain their structure and function throughout lifetime, and the way they evolve are closely linked. Epithelial tissues are ubiquitous in metazoans, covering the gut and internal branched organs, as well as the skin and its derivatives (ie, teeth). Here, we discuss in vitro, in vivo, and in silico studies on epithelial tissues to illustrate the conserved, dynamical, and complex aspects of their development. We then explore the implications of the dynamical and nonlinear nature of development on the evolution of their size and shape at the phenotypic and genetic levels. In rare cases, when the interplay between signaling and mechanics is well understood at the cell level, it is becoming clear that the structure of development leads to covariation of characters, an integration which in turn provides some predictable structure to evolutionary changes. We suggest that such nonlinear systems are prone to genetic drift, cryptic genetic variation, and context-dependent mutational effects. We argue that experimental and theoretical studies at the cell level are critical to our understanding of the phenotypic and genetic evolution of epithelial tissues, including carcinomas.

Abstract

The core of Evo-Devo lies in the intuition that the way tissues grow during embryonic development, the way they sustain their structure and function throughout lifetime, and the way they evolve are closely linked. Epithelial tissues are ubiquitous in metazoans, covering the gut and internal branched organs, as well as the skin and its derivatives (ie, teeth). Here, we discuss in vitro, in vivo, and in silico studies on epithelial tissues to illustrate the conserved, dynamical, and complex aspects of their development. We then explore the implications of the dynamical and nonlinear nature of development on the evolution of their size and shape at the phenotypic and genetic levels. In rare cases, when the interplay between signaling and mechanics is well understood at the cell level, it is becoming clear that the structure of development leads to covariation of characters, an integration which in turn provides some predictable structure to evolutionary changes. We suggest that such nonlinear systems are prone to genetic drift, cryptic genetic variation, and context-dependent mutational effects. We argue that experimental and theoretical studies at the cell level are critical to our understanding of the phenotypic and genetic evolution of epithelial tissues, including carcinomas.

Altmetrics

Downloads

1 download since deposited on 04 Aug 2016
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:07 Faculty of Science > Physics Institute
Dewey Decimal Classification:530 Physics
Uncontrolled Keywords:Morphogenesis; Evo-Devo; Morphodynamics; Simulation; Tinkering; Integration; Genetic architecture; Branching; Teeth; Cancer; Appendages; Wing; Innovation; Mechanics
Language:English
Date:5 May 2016
Deposited On:04 Aug 2016 09:19
Last Modified:05 Aug 2016 08:04
Publisher:Elsevier
Series Name:Current Topics in Developmental Biology
Number:119
ISSN:0070-2153
ISBN:9780124171947
Publisher DOI:https://doi.org/10.1016/bs.ctdb.2016.03.005
Related URLs:https://books.google.com/books?id=4vxZCgAAQBAJ&pg=PA227&lpg=PA227&dq=Chapter+Seven+%E2%80%93+Looking+Beyond+the+Genes:+The+Interplay+Between+Signaling+Pathways+and+Mechanics+in+the+Shaping+and+Diversification+of+Epithelial+Tissues&source=bl&ots=u8jPkvn-s2
PubMed ID:27282028

Download

[img]
Content: Accepted Version
Language: English
Filetype: PDF (Urdy et al 2016 post-print) - Registered users only until 5 May 2017
Size: 1MB
View at publisher
Embargo till: 2017-05-05

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations