UZH-Logo

Diffusion tensor magnetic resonance imaging of the human calf: comparison between 1.5 T and 3.0 T-preliminary results


Saupe, N; White, L M; Sussman, M S; Kassner, A; Tomlinson, G; Noseworthy, M D (2008). Diffusion tensor magnetic resonance imaging of the human calf: comparison between 1.5 T and 3.0 T-preliminary results. Investigative Radiology, 43(9):612-618.

Abstract

OBJECTIVES: To compare diffusion tensor-magnetic resonance imaging (DT-MRI) of human calf muscles at 1.5 T and 3.0 T, and to measure a number of quantitative parameters to characterize diffusion anisotropy in organized muscle tissue using similar imaging parameters. METHODS AND MATERIALS: After Institutional Review Board approval and informed consent, five healthy volunteers were studied. Imaging was performed on both 1.5 T and 3.0 T MR systems using the similar imaging protocol. Diffusion-sensitized single-shot spin-echo echo planar imaging pulse sequences were used to collect 2-dimensional images through the calf. Imaging was performed using b-values of 0, 300, 500, and 700 s/mm. Image analyses and tensor calculations were performed offline using DT imaging studio (Johns Hopkins University, Baltimore, MD). The eigenvalues (lambda1, lambda2, lambda3), trace of the diffusion tensor (TrD), fractional anisotropy, relative anisotropy, and volume ratio were calculated in 3 different calf muscles (medial and lateral gastrocnemius and soleus). Signal-to-noise ratios (SNRs) were compared for both field strengths (1.5 T and 3.0 T), the different muscles and all b-values. A regression analysis was performed to look at within-subject effects (linear mixed effect model). RESULTS: No significant differences were found between all quantitative measured DT-MRI parameters, b-values, and muscle groups at 3.0 T and 1.5 T (P = 0.105; P = 0.719). The mean of SNR on the 2 different field strengths (3.0:1.5 T) was 1.64, which was significantly different (P < 0.0001). Significant differences in SNR in all 3 muscles were found between sequences using b = 300 s/mm and 700 s/mm (P < 0.001; P = 0.006) and between sequences using b = 300 s/mm and 500 s/mm (P < 0.001; P = 0.03), and 500 s/mm and 700 s/mm (P = 0.005; P = 0.03), respectively, for medial gastrocnemius and soleus muscle. CONCLUSIONS: This study demonstrates useful parameters to perform DT-MRI at 1.5 T and 3.0 T. DT-MRI at 1.5 T and 3.0 T provide in vivo validation of quantitative structural analysis of human skeleletal muscle.

OBJECTIVES: To compare diffusion tensor-magnetic resonance imaging (DT-MRI) of human calf muscles at 1.5 T and 3.0 T, and to measure a number of quantitative parameters to characterize diffusion anisotropy in organized muscle tissue using similar imaging parameters. METHODS AND MATERIALS: After Institutional Review Board approval and informed consent, five healthy volunteers were studied. Imaging was performed on both 1.5 T and 3.0 T MR systems using the similar imaging protocol. Diffusion-sensitized single-shot spin-echo echo planar imaging pulse sequences were used to collect 2-dimensional images through the calf. Imaging was performed using b-values of 0, 300, 500, and 700 s/mm. Image analyses and tensor calculations were performed offline using DT imaging studio (Johns Hopkins University, Baltimore, MD). The eigenvalues (lambda1, lambda2, lambda3), trace of the diffusion tensor (TrD), fractional anisotropy, relative anisotropy, and volume ratio were calculated in 3 different calf muscles (medial and lateral gastrocnemius and soleus). Signal-to-noise ratios (SNRs) were compared for both field strengths (1.5 T and 3.0 T), the different muscles and all b-values. A regression analysis was performed to look at within-subject effects (linear mixed effect model). RESULTS: No significant differences were found between all quantitative measured DT-MRI parameters, b-values, and muscle groups at 3.0 T and 1.5 T (P = 0.105; P = 0.719). The mean of SNR on the 2 different field strengths (3.0:1.5 T) was 1.64, which was significantly different (P < 0.0001). Significant differences in SNR in all 3 muscles were found between sequences using b = 300 s/mm and 700 s/mm (P < 0.001; P = 0.006) and between sequences using b = 300 s/mm and 500 s/mm (P < 0.001; P = 0.03), and 500 s/mm and 700 s/mm (P = 0.005; P = 0.03), respectively, for medial gastrocnemius and soleus muscle. CONCLUSIONS: This study demonstrates useful parameters to perform DT-MRI at 1.5 T and 3.0 T. DT-MRI at 1.5 T and 3.0 T provide in vivo validation of quantitative structural analysis of human skeleletal muscle.

Citations

18 citations in Web of Science®
19 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 05 Feb 2009
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:September 2008
Deposited On:05 Feb 2009 19:18
Last Modified:05 Apr 2016 12:57
Publisher:Lippincott Wiliams & Wilkins
ISSN:0020-9996
Publisher DOI:10.1097/RLI.0b013e31817e909f
PubMed ID:18708854
Permanent URL: http://doi.org/10.5167/uzh-12607

Download

[img]
Filetype: PDF - Registered users only
Size: 1MB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations