Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-12617
Falsig, J; Nilsson, K P R; Knowles, T P J; Aguzzi, A (2008). Chemical and biophysical insights into the propagation of prion strains. HFSP Journal, 2(6):332-341.
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Transmissible spongiform encephalopathies (TSEs) are lethal infectious neurodegenerative diseases. TSEs are caused by prions, infectious agents lacking informational nucleic acids, and possibly identical with higher-order aggregates of the cellular glycolipoprotein PrPC. Prion strains are derived from TSE isolates that, even after inoculation into genetically identical hosts, cause disease with distinct patterns of protein aggregate deposition, incubation times, morphology of the characteristic brain damage, and cellular tropism. Most of these traits are relatively stable across serial passages. Here we review current techniques for studying prion strain differences in vivo and in cells, and discuss the strain phenomena in the general context of the knowledge gained from modeling prion fibril growth in vitro and in simple organisms.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||05 Feb 2009 12:09|
|Last Modified:||29 Nov 2013 20:04|
|Publisher:||International Human Frontier Science Program Organization|
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