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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1266

Ameri, K; Hammond, E M; Culmsee, C; Raida, M; Katschinski, D M; Wenger, R H; Wagner, E; Davis, R J; Hai, T; Denko, N; Harris, A L (2007). Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene, 26(2):284-289.

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Abstract

Solid tumors often have an inadequate blood supply, which results in large regions that are subjected to hypoxic or anoxic stress. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates much of the transcriptional response of cells to hypoxia. Activating transcription factor 3 (ATF3) is another transcription factor that responds to a variety of stresses and is often upregulated in cancer. We investigated the regulation of ATF3 by oxygen deprivation. ATF3 induction occurred most robustly under anoxia, is common, and it is not dependent on presence of HIF-1 or p53, but is sensitive to the inhibition of c-Jun NH2-terminal kinase activation and the antioxidant N-acetylcystein. ATF3 could also be induced by desferrioxamine but not by the mitochondrial poison cyanide or the nonspecific 2-oxoglutarate dioxygenase inhibitor dimethyloxalylglycine. We also show that anoxic ATF3 mRNA is more stable than normoxic mRNA providing a mechanism for this induction. Thus, this study demonstrates that the regulation of ATF3 under anoxia is independent of 2-oxoglutarate dioxygenase, HIF-1 and p53, presumably involving multiple regulatory pathways.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Language:English
Date:2007
Deposited On:11 Feb 2008 12:22
Last Modified:16 Jul 2014 19:23
Publisher:Nature Publishing Group
ISSN:0950-9232
Additional Information:Embargo ending July 11, 2007
Publisher DOI:10.1038/sj.onc.1209781
PubMed ID:16847457
Citations:Web of Science®. Times Cited: 39
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