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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1280

Hofer, T; Pohjanvirta, R; Spielmann, P; Viluksela, M; Buchmann, D P; Wenger, R H; Gassmann, M (2004). Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response. Biological Chemistry, 385(3-4):291-294.



Aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor-1alpha (HIF-1alpha) are conditionally regulated transcription factor subunits that form heterodimeric complexes with their common partner, AhR nuclear translocator (ARNT/HIF-1beta). Whereas the environmentally toxic compound 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) initiates the trans-activation activity of AhR:ARNT/HIF-1beta, hypoxic exposure stabilizes HIF-1alpha and functionally activates the HIF-1alpha:ARNT/HIF-1beta complex. To analyze a possible crosstalk between these two pathways in vivo, rats were given dioxin orally and/or were exposed to carbon monoxide (CO), causing functional anemia. We found that exposure to CO inhibited the xenobiotic response while dioxin application had no significant negative impact on hypoxia-mediated gene transcription.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Deposited On:11 Feb 2008 12:22
Last Modified:27 Nov 2013 23:31
Publisher:De Gruyter
Publisher DOI:10.1515/BC.2004.024
PubMed ID:15134343
Citations:Web of Science®. Times Cited: 11
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