Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-12910
Méret, M; Bienz, S (2008). Efficient and flexible solid-phase synthesis of N-hydroxypolyamine derivatives. European Journal of Organic Chemistry, (33):5518-5525.
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Orthogonally protected, N-hydroxylated, linear tri- and tetra-amines were efficiently synthesised on Merrifield resin, which was modified with a phenethyl bromide linker. The polyamine frameworks were convergently prepared from the centre with reductive aminations and nucleophilic substitutions to elongate the polyamine backbone. The required N-hydroxy groups were introduced during the cleavage of the polyamine derivatives from the resin through Cope elimination.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Department of Chemistry|
|Deposited On:||15 Feb 2009 09:48|
|Last Modified:||17 Jul 2014 00:08|
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