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Initial experiences using non-cultured autologous keratinocyte suspension for burn wound closure


Zweifel, C J; Contaldo, C; Köhler, C; Jandali, A; Künzi, W; Giovanoli, P (2008). Initial experiences using non-cultured autologous keratinocyte suspension for burn wound closure. Journal of Plastic, Reconstructive & Aesthetic Surgery, 61(11):e1-e4.

Abstract

Early complete wound closure and thus reduction of excessive scar formation still represent a major clinical challenge in severely burned patients. A novel concept to cover large burn wounds consists of the application of non-cultured epithelial cell suspension within the first days. Herein, we report our experiences with three patients treated with CellSpray XP. According to the amount of cell suspension required, a skin biopsy was harvested and then processed in an external laboratory. Two days later the suspension containing autologous non-cultured keratinocytes was applied using an aerosol system. All wounds healed rapidly and virtually no signs of hypertrophic scarring were observed 6 months later.

Abstract

Early complete wound closure and thus reduction of excessive scar formation still represent a major clinical challenge in severely burned patients. A novel concept to cover large burn wounds consists of the application of non-cultured epithelial cell suspension within the first days. Herein, we report our experiences with three patients treated with CellSpray XP. According to the amount of cell suspension required, a skin biopsy was harvested and then processed in an external laboratory. Two days later the suspension containing autologous non-cultured keratinocytes was applied using an aerosol system. All wounds healed rapidly and virtually no signs of hypertrophic scarring were observed 6 months later.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:November 2008
Deposited On:13 Feb 2009 13:45
Last Modified:05 Apr 2016 12:58
Publisher:Elsevier
ISSN:1748-6815
Publisher DOI:https://doi.org/10.1016/j.bjps.2007.07.015
PubMed ID:17869200

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