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New choices for patients needing kidney transplantation across antibody barriers


Higgins, R; Hathaway, M; Lowe, D; Zehnder, D; Krishnan, N; Hamer, R; Briggs, D (2008). New choices for patients needing kidney transplantation across antibody barriers. Journal of Renal Care, 34(2):85-93.

Abstract

Antibodies in the blood of a kidney transplant recipient can provide a barrier to transplantation, which is additional to the usual possibility of cellular rejection. The antibodies most frequently encountered are ABO (blood group) and human leucocyte antigen (HLA) (tissue-type) antibodies. About 250 living donor transplants each year in the United Kingdom have been stopped because of an antibody barrier. It is now possible to offer a choice of treatment modalities to these people, including exchange transplantation and antibody-incompatible transplantation. It is likely that both schemes will complement each other and both are available in the United Kingdom.

Antibodies in the blood of a kidney transplant recipient can provide a barrier to transplantation, which is additional to the usual possibility of cellular rejection. The antibodies most frequently encountered are ABO (blood group) and human leucocyte antigen (HLA) (tissue-type) antibodies. About 250 living donor transplants each year in the United Kingdom have been stopped because of an antibody barrier. It is now possible to offer a choice of treatment modalities to these people, including exchange transplantation and antibody-incompatible transplantation. It is likely that both schemes will complement each other and both are available in the United Kingdom.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Date:2008
Deposited On:03 Mar 2009 12:07
Last Modified:05 Apr 2016 12:58
Publisher:Wiley-Blackwell
ISSN:1755-6678
Publisher DOI:https://doi.org/10.1111/j.1755-6686.2008.00025.x
PubMed ID:18498573

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