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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13015

De Botton, D; Janett, F; Burger, D; Imboden, I; Kähn, W; Thun, R (2008). Influence of long-term treatment with equine somato-tropin (EquiGen®) on gonadal function in stallions with poor semen quality. Schweizer Archiv für Tierheilkunde, 150(4):157-165.

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The aim of the present study was to investigate the spermatogenic and Leydig cell activity in stallions with impaired semen quality after treatment with equine somatotropin. Experiments were performed using 18 adult clinically healthy stallions with poor semen quality which did not pass breeding soundness evaluation. The animals were randomly divided into a treatment (n = 9) and a control (n = 9) group. Over a period of 90 days, nine stallions received a daily intramuscular injection of 10 mg recombinant equine somatotropin (EquiGen, BresaGen Limited, Adelaide, Australia) and 9 control animals were injected with the same amount of physiological saline solution. During and until 2 months after treatment, semen characteristics and daily sperm output as well as plasma testosterone concentrations were determined monthly in all stallions. In addition, testosterone concentration measurement after stimulation with hCG was performed in all animals immediately before and at the end of the treatment period as well as 2 months later. Our results demonstrate that equine somatotropin (EquiGen) given daily in a dose of 10 mg per animal during 90 days had no significant effect neither on plasma testosterone concentrations and hCG-induced testosterone release nor on semen quality parameters in adult stallions with poor semen characteristics.


2 citations in Web of Science®
2 citations in Scopus®
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Other titles:Einfluss einer Langzeitbehandlung mit equinem Somatotropin (EquiGen®) auf die Hodenfunktion von Hengsten mit schlechter Samenqualität Effet d’un traitement à long terme à la somatotropine équine (EquiGen®) sur la fonction testiculaire d’étalons présentant une mauvaise qualité de semence Influenza di una cura a lungo termine con somatotropina equina (EquiGen®) sulla funzione dei testicoli di stalloni con una cattiva qualità di sperma
Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:Hengst - Samenqualität - Somatotropin - Testosteron - semen quality - somatotropin - stallion - testosterone
Deposited On:10 Feb 2009 14:22
Last Modified:05 Apr 2016 12:58
Publisher:Hans Huber
Additional Information:This article may not exactly replicate the final version published in Schweizer Archiv für Tierheilkunde. It is not the version of record and is therefore not suitable for citation.
Publisher DOI:10.1024/0036-7281.150.4.157
PubMed ID:18488716

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