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Walters, D K; Steinmann, P; Langsam, B; Schmutz, S; Born, W; Fuchs, B (2008). Identification of potential chemoresistance genes in osteosarcoma. Anticancer Research, 28(2A):673-679.

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Abstract

BACKGROUND: Osteosarcoma (OS) is an aggressive bone malignancy that primarily affects children and adolescents. Patients with metastatic disease at diagnosis have only a 20% survival rate. The poor survival rate of these patients is largely due to their lack of responsiveness to chemotherapy. However, the mechanisms underlying osteosarcoma chemoresistance remain unknown. MATERIALS AND METHODS: The effect of cisplatin, doxorubicin and etoposide was examined on OS cell lines. Affymetric Genechip analysis was used to examine differential gene expression. RESULTS: A correlation between increasing metastatic potential and increasing chemoresistance was observed in the MG-63 cell line and sub-line model. Microarray analysis of these cell lines revealed the differential expression of several genes potentially involved in chemoresistance including ABCG2, ADD3, NMT2, WNTSa and PTN. CONCLUSION: The identification of genes contributing to chemoresistance and determining the role these genes play is critical in characterizing patient responsiveness and overcoming chemoresistance in osteosarcoma patients.

Citations

21 citations in Web of Science®
20 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
DDC:610 Medicine & health
Language:English
Date:March 2008
Deposited On:09 Feb 2009 17:54
Last Modified:27 Nov 2013 20:45
Publisher:International Institute of Anticancer Research
ISSN:0250-7005
Official URL:http://www.iiar-anticancer.org/main.php?pid=6723&id=2&ch=52&gch=&volume=28&issue=2A&show=details&page=4
Related URLs:http://www.iiar-anticancer.org/ (Publisher)
PubMed ID:18507006

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