Biber, J; Gisler, S M; Hernando, N; Wagner, C A; Murer, H (2004). PDZ interactions and proximal tubular phosphate reabsorption. American Journal of Physiology: Renal Physiology, 287(5):F871-F875.
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In adults, the extent of renal reabsorption of P(i) and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-P(i) cotransporter NaPi-IIa (SLC34A1). Localization of this cotransporter is restricted to the apical membrane of proximal tubular cells, and its abundance is controlled by a number of factors and pathophysiological conditions. To guarantee a proper apical localization and specific regulated endocytosis of NaPi-IIa, an orchestrated pattern of protein interactions has to be envisaged. Attempts to screen for such interacting proteins resulted in the identification of a PDZ domain containing proteins. The purpose of this review is to discuss the roles of these PDZ proteins in proximal tubular Na-P(i) cotransport.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
|DDC:||570 Life sciences; biology|
|Date:||1 November 2004|
|Deposited On:||11 Feb 2008 12:22|
|Last Modified:||27 Nov 2013 19:50|
|Publisher:||American Physiological Society|
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