Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Murer, H; Biber, J (1997). Membrane traffic and control of proximal tubular sodium phosphate (Na/Pi)-cotransport. Wiener Klinische Wochenschrift, 109(12-13):441-444.

Full text not available from this repository.

Abstract

Phosphate (P(i)) is freely filtered at the glomerular capillaries and largely reabsorbed in the proximal tubule by a Na-dependent, secondary active transport mechanism. Two different brush border membrane Na/P(i)-cotransporters have recently been "cloned" (type I and type II). Only the type II transporter undergoes physiological regulation (e.g., diet, acid/base, parathyroid hormone); it is also involved in pathophysiological alterations of renal Pi-handling (e.g., X-linked hypophosphatemia). In recent experiments on rats and on tissue culture cells (Opossum kidney cells, OK cells) id was documented that manoeuvres leading to increased uptake involve membrane insertion (fast changes) and new synthesis of type II transporters (slow changes), whereas decreased Na/Pi-cotransport activity is associated with their specific membrane retrieval (fast changes) and lysosomal degradation (slow changes).

Citations

3 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Language:English
Date:27 June 1997
Deposited On:11 Feb 2008 12:22
Last Modified:27 Nov 2013 20:17
Publisher:Springer
ISSN:0043-5325
Related URLs:http://www.springer.at/periodicals/article_issue.jsp?articleID=xxxxxxxx1374xxxxxxxx0109&volumeIssueID=xxxxxxxx1368xxxxxxxx0108&periodicalID=0043-5325&supplement=null
PubMed ID:9261984

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page