Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Obermüller, N; Gretz, N; Kriz, W; van der Woude, F J; Reilly, R F; Murer, H; Biber, J; Witzgall, R (1997). Differentiation and cell polarity during renal cyst formation in the Han:SPRD (cy/+) rat, a model for ADPKD. American Journal of Physiology: Renal Physiology, 273(3 Pt 2):F357-F371.

Full text not available from this repository.

Abstract

Despite the recent positional cloning of genes responsible for autosomal dominant polycystic kidney disease (ADPKD), the exact pathogenetic mechanisms underlying this disorder are still unclear. To learn more about cyst formation, we investigated cell differentiation and cell polarity in the Han:SPRD (cy/+) rat between 21 days and 60 wk of age. At early stages of cyst development, alkaline phosphatase, aquaporin-1, NaSi-1 cotransporter, and Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) were expressed normally. Clusterin mRNA was only sparsely expressed at the onset of cystic degeneration and increased thereafter, being highest in noncystic nephron segments. In cyst wall cells, clusterin on the one hand and alkaline phosphatase, aquaporin-1, NaSi-1-cotransporter, and Na(+)-K(+)-ATPase on the other were expressed in a mutually exclusive fashion. No change in cell polarity could be observed at any stage. Our data therefore argue against a change in cell polarity and against an early arrest in normal tubular development during cyst formation in the Han:SPRD (cy/+) rat model of ADPKD but favor the hypothesis that tubular epithelia develop in an orderly fashion and degenerate thereafter.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Language:English
Date:01 September 1997
Deposited On:11 Feb 2008 13:22
Last Modified:28 Nov 2013 01:21
Publisher:American Physiological Society
ISSN:0002-9513
Related URLs:http://ajprenal.physiology.org/cgi/content/abstract/273/3/F357
PubMed ID:9321908
Citations:Web of Science®. Times Cited: 17
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page