Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive 

Schell, M J; Letcher, A J; Brearley, C A; Biber, J; Murer, H; Irvine, R F (1999). PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. FEBS Letters, 461(3):169-172.

Full text not available from this repository.


A cDNA cloned from its ability to stimulate inorganic phosphate uptake in Xenopus oocytes (phosphate uptake stimulator (PiUS)) shows significant similarity with inositol 1,4,5-trisphosphate 3-kinase. However, the expressed PiUS protein showed no detectable activity against inositol 1,4,5-trisphosphate, nor the 1,3,4,5- or 3,4,5, 6-isomers of inositol tetrakisphosphate, whereas it was very active in converting inositol hexakisphosphate (InsP(6)) to inositol heptakisphosphate (InsP(7)). PiUS is a member of a family of enzymes found in many eukaryotes and we discuss the implications of this for the functions of InsP(7) and for the evolution of inositol phosphate kinases.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Date:19 November 1999
Deposited On:11 Feb 2008 12:22
Last Modified:27 Nov 2013 17:40
Publisher DOI:10.1016/S0014-5793(99)01462-3
PubMed ID:10567691
Citations:Web of Science®. Times Cited: 50
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page