Quick Search:

uzh logo
Browse by:


Zurich Open Repository and Archive

Schell, M J; Letcher, A J; Brearley, C A; Biber, J; Murer, H; Irvine, R F (1999). PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. FEBS Letters, 461(3):169-172.

Full text not available from this repository.

View at publisher


A cDNA cloned from its ability to stimulate inorganic phosphate uptake in Xenopus oocytes (phosphate uptake stimulator (PiUS)) shows significant similarity with inositol 1,4,5-trisphosphate 3-kinase. However, the expressed PiUS protein showed no detectable activity against inositol 1,4,5-trisphosphate, nor the 1,3,4,5- or 3,4,5, 6-isomers of inositol tetrakisphosphate, whereas it was very active in converting inositol hexakisphosphate (InsP(6)) to inositol heptakisphosphate (InsP(7)). PiUS is a member of a family of enzymes found in many eukaryotes and we discuss the implications of this for the functions of InsP(7) and for the evolution of inositol phosphate kinases.


52 citations in Web of Science®
54 citations in Scopus®
Google Scholar™


Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Date:19 November 1999
Deposited On:11 Feb 2008 12:22
Last Modified:27 Nov 2013 17:40
Publisher DOI:10.1016/S0014-5793(99)01462-3
PubMed ID:10567691

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page