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Control of proximal tubular apical Na/Pi cotransport


Murer, H; Biber, J (1996). Control of proximal tubular apical Na/Pi cotransport. Experimental Nephrology, 4(4):201-204.

Abstract

Two renal proximal tubular apical sodium-dependent transport systems for phosphate (Na/Pi cotransporter) have been identified. Recent studies demonstrated that the abundance of the type II Na/Pi cotransporter in the brush border is critical for the capacity of phosphate reabsorption. Evidence was obtained that a change of apical Na/Pi cotransporters may occur via endo/ exocytic processes and via protein-synthesis-dependent mechanisms involving altered transcription and/or stability of mRNA. In addition, acute control of apical Na/Pi cotransport may occur via the pH dependence and electrogenicity of the Na/Pi cotransporter.

Two renal proximal tubular apical sodium-dependent transport systems for phosphate (Na/Pi cotransporter) have been identified. Recent studies demonstrated that the abundance of the type II Na/Pi cotransporter in the brush border is critical for the capacity of phosphate reabsorption. Evidence was obtained that a change of apical Na/Pi cotransporters may occur via endo/ exocytic processes and via protein-synthesis-dependent mechanisms involving altered transcription and/or stability of mRNA. In addition, acute control of apical Na/Pi cotransport may occur via the pH dependence and electrogenicity of the Na/Pi cotransporter.

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9 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:August 1996
Deposited On:11 Feb 2008 12:22
Last Modified:07 Jul 2016 14:38
Publisher:Karger
ISSN:1018-7782
Related URLs:http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=228540
PubMed ID:8864723
Permanent URL: http://doi.org/10.5167/uzh-1355

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