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Antisense and the kidney


Oberbauer, R; Murer, H; Schreiner, G F; Meyer, T W (1996). Antisense and the kidney. Kidney & Blood Pressure Research, 19(5):221-224.

Abstract

Antisense oligonucleotides are being used as gene-therapeutic agents. This short overview focuses on the in vivo kinetics and on potential in vivo applications for research purposes as well as therapeutic applications. The most promising experimental results have been obtained with oligonucleotides targeted against genes involved in cell proliferation, such as c-myc, c-myb, Kras, and cdc-2. High parenteral doses of such oligonucleotides have limited growth of experimental tumors, and local application of such oligonucleotides has limited neointimal proliferation in injured arteries. Therapeutic use of antisense in the kidney seems more distant. Because proximal tubule cells take up circulating oligonucleotides, transient suppression of proximal tubule message expression may be obtained following parenteral oligonucleotide administration. More sophisticated delivery systems, however, will be required to achieve antisense efficacy over longer periods and in other compartments of the kidney.

Antisense oligonucleotides are being used as gene-therapeutic agents. This short overview focuses on the in vivo kinetics and on potential in vivo applications for research purposes as well as therapeutic applications. The most promising experimental results have been obtained with oligonucleotides targeted against genes involved in cell proliferation, such as c-myc, c-myb, Kras, and cdc-2. High parenteral doses of such oligonucleotides have limited growth of experimental tumors, and local application of such oligonucleotides has limited neointimal proliferation in injured arteries. Therapeutic use of antisense in the kidney seems more distant. Because proximal tubule cells take up circulating oligonucleotides, transient suppression of proximal tubule message expression may be obtained following parenteral oligonucleotide administration. More sophisticated delivery systems, however, will be required to achieve antisense efficacy over longer periods and in other compartments of the kidney.

Citations

3 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1996
Deposited On:11 Feb 2008 12:22
Last Modified:05 Apr 2016 12:18
Publisher:Karger
ISSN:1420-4096
Publisher DOI:10.1159/000174079
PubMed ID:8956232

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