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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13684

Stopper, H; Walitza, S; Warnke, A; Gerlach, M (2008). Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate. Journal of Neural Transmission, 115(2):331-334.

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Abstract

Children affected by attention deficit/hyperactivity disorder are often treated with methylphenidate (MPH). Two years ago, an increase in genomic damage after 3 months of MPH treatment was reported by researchers from Texas, U.S.A., raising concern about potential carcinogenic effects. In a similar investigation conducted in Wuerzburg, Germany, we did not find a comparable elevation of genomic damage. MPH is not genotoxic in standard test systems, but yielded one positive result in a rodent carcinogenicity study at the highest test dose only (60-fold above therapeutic doses). In conclusion, changes in treatment strategies do not seem justified currently. Larger studies are under way and will hopefully eliminate any remaining doubt about potential genotoxic or carcinogenic consequences of MPH treatment.

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10 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:14 Feb 2009 19:03
Last Modified:27 Nov 2013 18:55
Publisher:Springer
ISSN:0300-9564
Publisher DOI:10.1007/s00702-007-0829-y
PubMed ID:17994183

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