Quick Search:

uzh logo
Browse by:

The deadline for the annual report 2015 is January 31st, 2016

Zurich Open Repository and Archive

Maintenance: Tuesday, 16.2.2015, 06:00-08:00

Maintenance work on various system components of ZORA. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13684

Stopper, H; Walitza, S; Warnke, A; Gerlach, M (2008). Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate. Journal of Neural Transmission, 115(2):331-334.

[img] PDF - Registered users only
View at publisher


Children affected by attention deficit/hyperactivity disorder are often treated with methylphenidate (MPH). Two years ago, an increase in genomic damage after 3 months of MPH treatment was reported by researchers from Texas, U.S.A., raising concern about potential carcinogenic effects. In a similar investigation conducted in Wuerzburg, Germany, we did not find a comparable elevation of genomic damage. MPH is not genotoxic in standard test systems, but yielded one positive result in a rodent carcinogenicity study at the highest test dose only (60-fold above therapeutic doses). In conclusion, changes in treatment strategies do not seem justified currently. Larger studies are under way and will hopefully eliminate any remaining doubt about potential genotoxic or carcinogenic consequences of MPH treatment.


10 citations in Web of Science®
12 citations in Scopus®
Google Scholar™



0 downloads since deposited on 14 Feb 2009
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Deposited On:14 Feb 2009 19:03
Last Modified:27 Nov 2013 18:55
Publisher DOI:10.1007/s00702-007-0829-y
PubMed ID:17994183

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page