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Pribanic, S; Loffing, J; Madjdpour, C; Bacic, D; Gisler, S M; Braunewell, K H; Biber, J; Murer, H (2003). Expression of visinin-like protein-3 in mouse kidney. Nephron Physiology, 95(4):76-82.

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Abstract

In renal proximal brush borders the Na/Pi cotransporter NaPi-IIa is part of a heteromultimeric complex including the PDZ proteins PDZK1 and NHERF1, which interact with the C terminus of NaPi-IIa. In this study, a yeast two-hybrid screen against the N terminus of the Na/Pi cotransporter NaPi-IIa was performed. Thereby we identified visinin-like protein-3 (VILIP-3), a member of neuronal calcium sensors. In this study, expression and protein localization of VILIP-3 in the mouse kidney was performed by immunofluorescence and RT-PCR using laser-assisted microdissected nephron segments. VILIP-3 was found to be abundant in distal and collecting ducts where it partly colocalized with calbindin D28K. In addition VILIP-3 was observed in the brush borders of proximal tubular S1 and S3 segments of both superficial and deep nephrons.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Language:English
Date:2003
Deposited On:11 Feb 2008 13:22
Last Modified:23 Nov 2012 13:26
Publisher:Karger
ISSN:0028-2766
Publisher DOI:10.1159/000074844
PubMed ID:14694264
Citations:Google Scholarā„¢

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