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DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors


Scheuermann, J; Dumelin, C E; Melkko, S; Zhang, Y; Mannocci, L; Jaggi, M; Sobek, J; Neri, D (2008). DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors. Bioconjugate Chemistry, 19(3):778-785.

Abstract

Encoded self-assembling chemical (ESAC) libraries are characterized by the covalent display of chemical moieties at the extremity of self-assembling oligonucleotides carrying a unique DNA sequence for the identification of the corresponding chemical moiety. We have used ESAC library technology in a two-step selection procedure for the identification of novel inhibitors of stromelysin-1 (MMP-3), a matrix metalloproteinase involved in both physiological and pathological tissue remodeling processes, yielding novel inhibitors with micromolar potency.

Encoded self-assembling chemical (ESAC) libraries are characterized by the covalent display of chemical moieties at the extremity of self-assembling oligonucleotides carrying a unique DNA sequence for the identification of the corresponding chemical moiety. We have used ESAC library technology in a two-step selection procedure for the identification of novel inhibitors of stromelysin-1 (MMP-3), a matrix metalloproteinase involved in both physiological and pathological tissue remodeling processes, yielding novel inhibitors with micromolar potency.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Functional Genomics Center Zurich
08 University Research Priority Programs > Systems Biology / Functional Genomics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2008
Deposited On:19 Feb 2009 11:03
Last Modified:05 Apr 2016 13:01
Publisher:American Chemical Society
ISSN:1043-1802
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1021/bc7004347
PubMed ID:18254582
Permanent URL: http://doi.org/10.5167/uzh-13771

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