Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13771

Scheuermann, J; Dumelin, C E; Melkko, S; Zhang, Y; Mannocci, L; Jaggi, M; Sobek, J; Neri, D (2008). DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors. Bioconjugate Chemistry, 19(3):778-785.

[img] PDF - Registered users only
View at publisher


Encoded self-assembling chemical (ESAC) libraries are characterized by the covalent display of chemical moieties at the extremity of self-assembling oligonucleotides carrying a unique DNA sequence for the identification of the corresponding chemical moiety. We have used ESAC library technology in a two-step selection procedure for the identification of novel inhibitors of stromelysin-1 (MMP-3), a matrix metalloproteinase involved in both physiological and pathological tissue remodeling processes, yielding novel inhibitors with micromolar potency.


43 citations in Web of Science®
42 citations in Scopus®
Google Scholar™



0 downloads since deposited on 19 Feb 2009
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Functional Genomics Center Zurich
08 University Research Priority Programs > Systems Biology / Functional Genomics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:19 Feb 2009 11:03
Last Modified:05 Apr 2016 13:01
Publisher:American Chemical Society
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1021/bc7004347
PubMed ID:18254582

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page