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The renal type IIa Na/Pi cotransporter: structure-function relationships.


Murer, H; Köhler, K; Lambert, G; Stange, G; Biber, J; Forster, I C (2002). The renal type IIa Na/Pi cotransporter: structure-function relationships. Cell Biochemistry and Biophysics, 36(2-3):215-220.

Abstract

The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling. In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well as particular regions of the transporter protein ("molecular domains") that potentially determine transport characteristics.

The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling. In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well as particular regions of the transporter protein ("molecular domains") that potentially determine transport characteristics.

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1 citation in Web of Science®
2 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2002
Deposited On:11 Feb 2008 12:23
Last Modified:05 Apr 2016 12:18
Publisher:Springer
ISSN:1085-9195
Publisher DOI:10.1385/CBB:36:2-3:215
PubMed ID:12139407

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