Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13973

Menzies, S W; Kreusch, J; Byth, K; Pizzichetta, M A; Marghoob, A; Braun, R; Malvehy, J; Puig, S; Argenziano, G; Zalaudek, I; Rabinovitz, H S; Oliviero, M; Cabo, H; Ahlgrimm-Siess, V; Avramidis, M; Guitera, P; Soyer, H P; Ghigliotti, G; Tanaka, M; Perusquia, A M; Pagnanelli, G; Bono, R; Thomas, L; Pellacani, G; Langford, D; Piccolo, D; Terstappen, K; Stanganelli, I; Llambrich, A; Johr, R (2008). Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Archives of Dermatology, 144(9):1120-1127.

[img]Accepted Version
PDF - Registered users only
View at publisher
[img] PDF - Registered users only


OBJECTIVE: To determine the predictive dermoscopic features of amelanotic and hypomelanotic melanoma. DESIGN: A total of 105 melanomas (median Breslow thickness, 0.76 mm), 170 benign melanocytic lesions, and 222 nonmelanocytic lesions lacking significant pigment (amelanotic, partially pigmented, and light colored) were imaged using glass-plate dermoscopy devices and scored for 99 dermoscopic features. Diagnostic models were derived from and tested on independent randomly selected lesions. SETTING: Predominantly hospital-based clinics from 5 continents. MAIN OUTCOME MEASURES: Sensitivity, specificity, and odds ratios for individual features and models for the diagnosis of melanoma and malignancy. RESULTS: The most significant negative predictors of melanoma were having multiple (>3) milialike cysts (odds ratio, 0.09; 95% confidence interval, 0.01-0.64), comma vessels with a regular distribution (0.10; 0.01-0.70), comma vessels as the predominant vessel type (0.16; 0.05-0.52), symmetrical pigmentation pattern (0.18; 0.09-0.39), irregular blue-gray globules (0.20; 0.05-0.87), and multiple blue-gray globules (0.28; 0.10-0.81). The most significant positive predictors were having a blue-white veil (odds ratio,13; 95% confidence interval, 3.9-40.0), scarlike depigmentation (4.4; 2.4-8.0), multiple blue-gray dots (3.5; 1.9-6.4), irregularly shaped depigmentation (3.3; 2.0-5.3), irregular brown dots/globules (3.2; 1.8-5.6), 5 to 6 colors (3.2; 1.6-6.3), and predominant central vessels (3.1; 1.6-6.0). A simple model distinguishing melanomas from all nonmelanomas had a sensitivity of 70% and a specificity of 56% in the test set. A model distinguishing all malignant lesions from benign lesions had a sensitivity of 96% and a specificity of 37%. Conclusion Although the diagnostic accuracy of dermoscopy for melanoma lacking significant pigment is inferior to that of more pigmented lesions, features distinguishing the former from benign lesions can be visualized on dermoscopic evaluation.


103 citations in Web of Science®
116 citations in Scopus®
Google Scholar™



1 download since deposited on 26 Feb 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Date:September 2008
Deposited On:26 Feb 2009 15:19
Last Modified:05 Apr 2016 13:01
Publisher:American Medical Association
Publisher DOI:10.1001/archderm.144.9.1120
PubMed ID:18794455

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page