Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13979
Oberhuber, C; Bulley, S M; Ballmer-Weber, B K; Bublin, M; Gaier, S; DeWitt, A M; Briza, P; Hofstetter, G; Lidholm, J; Vieths, S; Hoffmann-Sommergruber, K (2008). Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Molecular Nutrition & Food Research, 52(Suppl ):S230-S240.
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Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||26 Feb 2009 12:46|
|Last Modified:||07 Apr 2015 07:32|
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