Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13979
Oberhuber, C; Bulley, S M; Ballmer-Weber, B K; Bublin, M; Gaier, S; DeWitt, A M; Briza, P; Hofstetter, G; Lidholm, J; Vieths, S; Hoffmann-Sommergruber, K (2008). Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Molecular Nutrition & Food Research, 52(Suppl ):S230-S240.
- Registered users only
View at publisher
Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis.
2 downloads since deposited on 26 Feb 2009
0 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|DDC:||610 Medicine & health|
|Deposited On:||26 Feb 2009 12:46|
|Last Modified:||27 Nov 2013 20:52|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page