Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-13980

Van Den Hauwe , O; Schneider, M; Sahin, A; Van Peteghem, C H; Naegeli, H (2003). Immunochemical screening and liquid chromatographic-tandem mass spectrometric confirmation of drug residues in edible tissues of calves injected with a therapeutic dose of the synthetic glucocorticoids dexamethasone and flumethasone. Journal of Agricultural and Food Chemistry, 51(1):326-330.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

A field study was performed to assess the drug residue level in edible tissues after a therapeutic application of the synthetic glucocorticoids dexamethasone and flumethasone. Three diseased calves were injected intramuscularly with a commercial batch of dexamethasone esters and slaughtered 72 h after treatment. Another three calves were injected intramuscularly with an aqueous flumethasone preparation and slaughtered 24 h later. Residues of synthetic glucocorticoids in liver, muscle, kidney, and urine were assessed by competitive enzyme immunoassay. All dexamethasone concentrations exceeded the maximal residue level of 0.75 microg/kg in muscle and kidney and 2 microg/kg in the liver. The presence of both dexamethasone and flumethasone in the liver was confirmed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). These results indicate that liver tissue provides a suitable matrix to monitor the presence of illegal residues of synthetic glucocorticoids in slaughtered animals.

Citations

18 citations in Web of Science®
20 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 27 Mar 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology
DDC:570 Life sciences; biology
Language:English
Date:2003
Deposited On:27 Mar 2009 06:47
Last Modified:27 Nov 2013 22:02
Publisher:American Chemical Society
ISSN:0021-8561
Funders:others
Publisher DOI:10.1021/jf020533m
PubMed ID:12502428

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page