Kebir, Hania; Kreymborg, Katharina; Ifergan, Igal; Dodelet-Devillers, Aurore; Cayrol, Romain; Bernard, Monique; Giuliani, Fabrizio; Arbour, Nathalie; Becher, Burkhard; Prat, Alexandre (2007). Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Medicine, 13(10):1173-1175.
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Abstract
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology |
| DDC: | 610 Medicine & health |
| Language: | English |
| Date: | 2007 |
| Deposited On: | 20 Jun 2012 09:43 |
| Last Modified: | 23 Nov 2012 15:34 |
| Publisher: | Nature Publishing Group |
| ISSN: | 1078-8956 |
| Publisher DOI: | 10.1038/nm1651 |
| PubMed ID: | 17828272 |
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