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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation


Kebir, Hania; Kreymborg, Katharina; Ifergan, Igal; Dodelet-Devillers, Aurore; Cayrol, Romain; Bernard, Monique; Giuliani, Fabrizio; Arbour, Nathalie; Becher, Burkhard; Prat, Alexandre (2007). Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Medicine, 13(10):1173-1175.

Abstract

T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.

Abstract

T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.

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629 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2007
Deposited On:20 Jun 2012 07:43
Last Modified:05 Apr 2016 13:02
Publisher:Nature Publishing Group
ISSN:1078-8956
Publisher DOI:https://doi.org/10.1038/nm1651
PubMed ID:17828272

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