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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1422

Hernando, N; Gisler, S M; Pribanic, S; Déliot, N; Capuano, P; Wagner, C A; Moe, O W; Biber, J; Murer, H (2005). NaPi-IIa and interacting partners. Journal of Physiology, 567(1):21-26.

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Regulation of renal proximal tubular reabsorption of phosphate (Pi) is one of the critical steps in Pi homeostasis. Experimental evidence suggests that this regulation is achieved mainly by controlling the apical expression of the Na+-dependent Pi cotransporter type IIa (NaPi-IIa) in proximal tubules. Only recently have we started to obtain information regarding the molecular mechanisms that control the apical expression of NaPi-IIa. The first critical observation was the finding that truncation of only its last three amino acid residues has a strong effect on apical expression. A second major finding was the observation that the last intracellular loop of NaPi-IIa contains sequence information that confers parathyroid hormone (PTH) sensitivity. The use of the above domains of the cotransporter in yeast two-hybrid (Y2H) screening allowed the identification of proteins interacting with NaPi-IIa. Biochemical and morphological, as well as functional, analyses have allowed us to obtain insights into the physiological roles of such interactions, although our present knowledge is still far from complete.


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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Date:15 August 2005
Deposited On:11 Feb 2008 12:23
Last Modified:05 Apr 2016 12:18
Publisher DOI:10.1113/jphysiol.2005.087049
PubMed ID:15890704

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