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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-14237

Cozzio, A; French, L E (2008). T-cell clonality assays: how do they compare? Journal of Investigative Dermatology, 128(4):771-773.

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The distinction between certain benign cutaneous lymphocytic infiltrates and cutaneous T-cell lymphoma (CTCL) can be a challenging problem in clinical practice. An imperfect but useful tool in this circumstance is the analysis of T-cell clonality or monoclonality by assessing T-cell receptor (TCR) gene rearrangements. "Monoclonality" describes the origin of a specific human malignant tumor from one single cell from which the entire tumor is derived. The term is used to describe the early steps in tumorigenesis; in later stages of tumor growth and progression, monoclonal tumor cells may acquire a mutator phenotype, rendering the genome unstable. The resulting genetic heterogeneity may ultimately lead to subclones in the formerly monoclonal population of tumor cells.


8 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Date:April 2008
Deposited On:18 Feb 2009 16:48
Last Modified:05 Apr 2016 13:02
Publisher:Nature Publishing Group
Publisher DOI:10.1038/jid.2008.49
PubMed ID:18337708

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