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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-143

Benquet, P; Gee, C E; Gerber, U (2002). Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. Journal of Neuroscience, 22(22):9679-9686.



Molecular processes regulating the gain of NMDA receptors modulate diverse physiological and pathological responses in the CNS. Group I metabotropic glutamate receptors (mGluRs), which neighbor NMDA receptors and which can be coactivated by synaptically released glutamate, couple to several different second messenger pathways, each of which could target NMDA receptors. In CA3 pyramidal cells we show that the activation of mGluR1 potentiates NMDA current via a G-protein-independent mechanism involving Src kinase activation. In contrast, mGluR5-mediated enhancement of NMDA current requires G-protein activation, triggering a signaling cascade including protein kinase C and Src. These results indicate that one neurotransmitter, glutamate, can activate two distinct and independent signaling systems to target the same effector. These two pathways are likely to contribute significantly to the highly differentiated control of NMDA receptor function.


114 citations in Web of Science®
126 citations in Scopus®
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52 downloads since deposited on 11 Feb 2008
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Feb 2008 12:13
Last Modified:28 Nov 2013 00:12
Publisher:Society for Neuroscience
Additional Information:Holder of copyright: The Society for Neuroscience
Related URLs:http://www.jneurosci.org/cgi/content/abstract/22/22/9679
PubMed ID:12427823

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