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Recent advances in renal phosphate transport.


Hernando, N; Biber, J; Forster, I C; Murer, H (2005). Recent advances in renal phosphate transport. Therapeutic Apheresis and Dialysis, 9(4):323-327.

Abstract

Phosphate (Pi) homeostasis is achieved by adjusting the intestinal absorption and the renal excretion. Renal proximal reabsorption of Pi is regulated by controlling the amount of NaPi-IIa cotransporters in the brush border membrane of proximal tubules. Therefore, the understanding of the molecular mechanisms that control the apical expression of NaPi-IIa is required to have a full picture of how phosphate balancing takes place. In this review we will summarize our present knowledge about the mechanisms involved in the regulation of the apical expression and membrane retrieval of this family of transporters.

Phosphate (Pi) homeostasis is achieved by adjusting the intestinal absorption and the renal excretion. Renal proximal reabsorption of Pi is regulated by controlling the amount of NaPi-IIa cotransporters in the brush border membrane of proximal tubules. Therefore, the understanding of the molecular mechanisms that control the apical expression of NaPi-IIa is required to have a full picture of how phosphate balancing takes place. In this review we will summarize our present knowledge about the mechanisms involved in the regulation of the apical expression and membrane retrieval of this family of transporters.

Citations

6 citations in Web of Science®
7 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 August 2005
Deposited On:11 Feb 2008 12:23
Last Modified:05 Apr 2016 12:18
Publisher:Wiley-Blackwell
ISSN:1744-9979
Publisher DOI:10.1111/j.1744-9987.2005.00290.x
PubMed ID:16076375

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