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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-14371

Katz, O; Gil, L; Lifshitz, L; Prutchi-Sagiv, S; Gassmann, M; Mittelman, M; Neumann, D (2007). Erythropoietin enhances immune responses in mice. European Journal of Immunology, 37(6):1584-1593.

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Abstract

Erythropoietin (Epo) is the main erythropoietic hormone. Recombinant human Epo (rHuEpo) is thus used in clinical practice for the treatment of anemia. Accumulating data reveals that Epo exerts pleiotropic activities. We have previously shown an anti-neoplastic activity of Epo in murine multiple myeloma (MM) models, and in MM patients. Our findings that this anti-neoplastic effect operates via CD8+ T lymphocytes led us to hypothesize that Epo possesses a wider range of immunomodulatory functions. Here we demonstrate the effect of Epo on B lymphocyte responses, focusing on three experimental models: (i) tumor-bearing mice, (5T2 MM mouse); (ii) antigen-injected healthy mice; and (iii) antigen-injected transgenic mice (tg6), overexpressing human Epo. In the MM model, despite bone marrow dysfunction, Epo-treated mice retained higher levels of endogenous polyclonal immunoglobulins, compared to their untreated controls. In both Epo-treated wild type and tg6 mice, Epo effect was manifested in the higher levels of splenocyte proliferative response induced in vitro by lipopolysaccharide. Furthermore, these mice had increased in vivo production of anti-dinitrophenyl (DNP) antibodies following immunization with DNP-keyhole limpet hemocyanin. Epo-treated mice showed an enhanced immune response also to the clinically relevant hepatitis B surface antigen. These findings suggest a potential novel use of rHuEpo as an immunomodulator.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:June 2007
Deposited On:20 Mar 2009 14:17
Last Modified:27 Nov 2013 22:28
Publisher:Wiley-Blackwell
ISSN:0014-2980
Additional Information:Comment in: Eur J Immunol. 2007 Jun;37(6):1427-30.
Publisher DOI:10.1002/eji.200637025
PubMed ID:17458859
Citations:Web of Science®. Times Cited: 34
Google Scholar™
Scopus®. Citation Count: 34

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