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Wenger, R H; Camenisch, G; Desbaillets, I; Chilov, D; Gassmann, M (1998). Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction. Cancer Research, 58(24):5678-5680.

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Abstract

Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells with diminished apoptotic potential. It has been proposed that the hypoxia-inducible factor-1 (HIF-1) alpha subunit binds to p53 and protects it from proteasomal degradation. However, we found that hypoxic conditions that strongly induce HIF-1-dependent endogenous gene expression as well as HIF-1alpha protein neither induce p53-dependent gene expression nor p53 protein. The iron chelator deferoxamine induced both HIF-1alpha and p53, but p53 up-regulation could still be detected in HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha activation contribute to oxygen-regulated p53 induction.

Citations

67 citations in Web of Science®
66 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
Language:English
Date:1998
Deposited On:11 Feb 2008 12:23
Last Modified:27 Nov 2013 21:51
Publisher:American Association for Cancer Research
ISSN:0008-5472
Related URLs:http://cancerres.aacrjournals.org/cgi/content/abstract/58/24/5678
PubMed ID:9865721

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