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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-14441

Bilik, K U; Ergüven, E; Klussmann, S; Jarosch, F; Wielinga, P Y; Lutz, T A; Riediger, T (2007). In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer. NeuroReport, 18(17):1855-1859.

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Abstract

The anorectic and dipsogenic effects of the pancreatic hormone amylin are mediated by the area postrema and the subfornical organ. We tested the effectiveness of a new amylin antagonist, a so-called RNA Spiegelmer, by electrophysiological in-vitro recordings from the rat subfornical organ and by immunohistological c-Fos studies in the area postrema. Amylin's excitatory effect on subfornical organ neurons was blocked by the anti-amylin Spiegelmer. Peripheral administration 5 h prior to amylin also suppressed the amylin-induced activation (c-Fos expression) in the area postrema. The biostable anti-amylin Spiegelmer may be therapeutically beneficial in conditions associated with high plasma amylin levels, such as cancer anorexia occurring during certain pancreatic tumors.

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4 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:19 November 2007
Deposited On:19 Mar 2009 18:07
Last Modified:23 Nov 2012 13:03
Publisher:Lippincott Wiliams & Wilkins
ISSN:0959-4965
Publisher DOI:10.1097/WNR.0b013e3282f1ab04
PubMed ID:18090326

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