Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Koller, M M; Cowman, R A; Humphreys-Beher, M G; Scarpace, P J (2001). An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats. Experimental Gerontology, 36(1):141-157.

Full text not available from this repository.

Abstract

Cyclic antidepressants are still a dominating group of psychotherapeutic drugs used in the treatment of depression. Dry mouth is one of their major side effects. In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15-day washout period on different parameters in parotid gland function in aging rats. We hypothesized that glandular function would be decreased, and recovery delayed with age. Drug treatment affected body weight, glandular weight, DNA synthesis, and the concentration of soluble and structural membrane proteins. Surprisingly, parotid flow rate was increased with desipramine in all ages. While the concentration of secreted proteins was generally decreased with treatment, total proteins secreted were quite stable. SDS/PAGE analysis revealed prominent changes with desipramine. Amylase activity was depressed with treatment, but only low residual cellular enzyme activity was detected in the glandular supernatant. Therefore, a secretory impairment with desipramine was excluded. The content of the antimicrobial proteins peroxidase and lysozyme was increased with desipramine in all age groups. Most parameters measured revealed delayed recovery with age. These data indicate that the tricyclic antidepressant desipramine has profound effects on parotid gland function, accented with age.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Masticatory Disorders and Complete Dentures, Geriatric and Special Care Dentistry
DDC:610 Medicine & health
Language:English
Date:01 January 2001
Deposited On:11 Feb 2008 13:23
Last Modified:28 Nov 2013 01:56
Publisher:Elsevier
ISSN:0531-5565
Publisher DOI:10.1016/S0531-5565(00)00188-1
PubMed ID:11162918
Citations:Web of Science®. Times Cited: 2
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page