Weber, F E; Eyrich, G; Grätz, K W; Thomas, R M; Maly, F E; Sailer, H F (2001). Disulfide bridge conformers of mature BMP are inhibitors for heterotopic ossification. Biochemical and Biophysical Research Communications (BBRC), 286(3):554-558.
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Heterotopic ossification is a frequent complication in patients who have suffered head and neck traumas or undergone total hip replacement. Heterotopic ossification occurs when osteogenic precursor cells present at the ectopic site receive the necessary signal(s) to differentiate into osteoblasts. At the protein level, the key factors in differentiation of cells to the osteogenic lineage are BMPs. Stable BMP variants derived from the identical amino acid sequence but with different disulfide bridge configurations have been investigated and found to be capable of inhibiting ossification in vitro and in vivo in rodents. These findings provide a concept for the straightforward development of a novel class of BMP antagonists that could lead to new treatments for traumatically and genetically induced heterotopic ossification and also, possibly, for disorders in which other members of the TGF-beta superfamily are involved.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > Center for Dental Medicine > Clinic for Cranio-Maxillofacial Surgery|
|DDC:||610 Medicine & health|
|Date:||24 August 2001|
|Deposited On:||11 Feb 2008 13:23|
|Last Modified:||27 Nov 2013 22:13|
|Citations:||Web of Science®. Times cited: 15|
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