Heuss, C; Scanziani, M; Gähwiler, B H; Gerber, U (1999). G-protein-independent signaling mediated by metabotropic glutamate receptors. Nature Neuroscience, 2(12):1070-1077.
Full text not available from this repository.
Synaptically released glutamate activates ionotropic and metabotropic receptors at central synapses. Metabotropic glutamate receptors (mGluRs) are thought to modulate membrane conductances through transduction cascades involving G proteins. Here we show, in CA3 pyramidal cells from rat hippocampus, that synaptic activation of type 1 mGluRs by mossy fiber stimulation evokes an excitatory postsynaptic response independent of G-protein function, while inhibiting an afterhyperpolarization current through a G-protein-coupled mechanism. Experiments using peptide activators and specific inhibitors identified a Src-family protein tyrosine kinase as a component of the G-protein-independent transduction pathway. These results represent the first functional evidence for a dual signaling mechanism associated with a heptahelical receptor such as mGluR1, in which intracellular transduction involves activation of either G proteins or tyrosine kinases.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > Brain Research Institute|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||11 Feb 2008 12:13|
|Last Modified:||27 Nov 2013 23:06|
|Publisher:||Nature Publishing Group|
|Citations:||Web of Science®. Times Cited: 114|
Scopus®. Citation Count: 118
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page