Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-15726

Bernauer, W; Thiel, M A; Rentsch, K M (2008). Phosphate concentration in ophthalmic corticoid preparations. Graefe's Archive for Clinical and Experimental Ophthalmology, 246(7):975-978.

[img]PDF - Registered users only
1112Kb

Abstract

BACKGROUND: Topical preparations, high in phosphate, may cause calcification when used on a damaged corneal surface. The knowledge of the phosphate concentration in medications helps to prevent corneal calcifications. Our study gives an overview of the amount of phosphate contained in ophthalmic corticoid preparations. METHODS: Samples of 38 commercially available corticoid preparations were tested. The quantification of phosphate was performed using the molybdate method on a Modular P autoanalyzer. RESULTS: 18 of 38 preparations (47%) had a phosphate concentration above physiological levels (>1.45 mmol/l). It varied greatly, and ranged from less than 0.1 mmol/l (18 preparations) to 62.6 mmol/l. The corticoids that were tested included betamethasone sodium phosphate (18.3-35.5 mmol/l), dexamethasone (0.1-17.6 mmol/l), dexamethasone sodium phosphate (<0.1-62.6 mmol/l), fluorometholone (<0.1-22.5 mmol/l), and prednisolone acetate (<0.1-0.5 mmol/l). CONCLUSIONS: The phosphate concentration in corticoid-phosphate formulations varies greatly, and is mainly determined by the chosen buffer. The prednisolone acetate preparations showed physiological phosphate concentrations. For a treatment on a damaged corneal surface, preparations with physiological phosphate concentrations should be used.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
DDC:610 Medicine & health
540 Chemistry
Language:English
Date:2008
Deposited On:19 Feb 2009 14:40
Last Modified:27 Nov 2013 19:37
Publisher:Springer
ISSN:0721-832X
Publisher DOI:10.1007/s00417-008-0788-5
PubMed ID:18357463
Citations:Web of Science®. Times Cited: 1
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page