Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-15751

Turello, R; Rentsch, K; Di Paolo, E; Beck Popovic, M (2008). Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism. Pediatric Blood & Cancer, 50(1):154-156.

[img] PDF - Registered users only
View at publisher


We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX). Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr. The patient recovered from renal failure and no other side effects were observed. Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity.


8 citations in Web of Science®
10 citations in Scopus®
Google Scholar™



2 downloads since deposited on 25 Feb 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Deposited On:25 Feb 2009 14:27
Last Modified:05 Apr 2016 13:04
Additional Information:Wiley – Full text available online
Publisher DOI:10.1002/pbc.21176
Official URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/114200122/PDFSTART
PubMed ID:17387702

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page