Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-15751
Turello, R; Rentsch, K; Di Paolo, E; Beck Popovic, M (2008). Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism. Pediatric Blood & Cancer, 50(1):154-156.
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We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX). Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr. The patient recovered from renal failure and no other side effects were observed. Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry|
|Dewey Decimal Classification:||610 Medicine & health
|Deposited On:||25 Feb 2009 14:27|
|Last Modified:||27 Nov 2013 21:53|
|Additional Information:||Wiley – Full text available online|
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