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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-15816

Achatz-Straussberger, G; Zaborsky, N; Königsberger, S; Luger, E O; Lamers, M; Crameri, R; Achatz, G (2008). Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR. European Journal of Immunology, 38(11):3167-3177.

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Truncation of the cytoplasmic tail of membrane-bound IgE in vivo results in lower serum IgE levels, decreased numbers of IgE-secreting plasma cells and the abrogation of specific secondary immune responses. Here we present mouse strain KN1 that expresses a chimeric epsilon-gamma1 BCR, consisting of the extracellular domains of the epsilon gene and the transmembrane and cytoplasmic domains of the gamma1 gene. Thus, differences in the IgE immune response of KN1 mice reflect the influence of the "gamma1-mediated signalling" of mIgE bearing B cells. KN1 mice show an increased serum IgE level, resulting from an elevated number of IgE-secreting cells. Although the primary IgE immune response in KN1 mice is inconspicuous, the secondary response is far more robust. Most strikingly, IgE-antibody secreting cells with "gamma1-signalling history" migrate more efficiently towards the chemokine CXCL12, which guides plasmablasts to plasma cell niches, than IgE-antibody secreting cells with WT "epsilon-signalling history". We conclude that IgE plasmablasts have an intrinsic, lower chance to contribute to the long-lived plasma cell pool than IgG1 plasmablasts.


19 citations in Web of Science®
19 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Deposited On:24 Feb 2009 11:03
Last Modified:05 Apr 2016 13:04
Additional Information:The attached file is a preprint (accepted version) of an article published in Eur. J. Immunol. 2008. 38: 3167–3177
Publisher DOI:10.1002/eji.200838456
PubMed ID:18925577

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