Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-15938
Knabenhans, M A. 13N-ammonia myocardial perfusion imaging with hybrid PET/CT: impact on clinical decision-making and cost-effectiveness. 2007, University of Zurich, Faculty of Medicine.
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To determine the impact of 13N-ammonia myocardial perfusion positron emission tomography-computed tomography (PET/CT) hybrid imaging on clinical decision-making and its cost-effectiveness.
Methods: One hundred consecutive patients (28 women, 72 men; mean age 60.9�12.0 years; range 24-85 years) underwent 13N-ammonia PET/CT (CT was only used for attenuation correction) scanning to assess myocardial perfusion in patients with known (n=79) or suspected (n=8) coronary artery disease (CAD), or for suspected small vessel disease (SVD)(n=13). Prior to PET/CT the referring physician was asked to determine patient treatment if PET/CT would not be available. Four weeks after PET/CT patient management was re-assessed for each patient individually.
Results: Prior to PET/CT management strategies would have been: diagnostic angiography (62/100 patients), percutaneous coronary intervention (PCI) (6/100), coronary artery bypass grafting (CABG) (3/100), transplantation (1/100), or conservative medical treatment (28/100). After PET/CT scanning treatment strategies were altered in 78 patients leading to: diagnostic angiography (0/100), PCI (20/100), CABG (3/100), transplantation (1/100), or conservative medical treatment (76/100). Patient management followed the recommendations of PET/CT findings in 97% of the cases. Cost-effectiveness analysis revealed lower costs of $273/patient as a result of PET/CT scanning.
Conclusion: In a population with a high prevalence of CAD, PET/CT is cost-effective and has an important impact on patient management.
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|Referees:||Kaufmann P A|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||18 Mar 2009 12:55|
|Last Modified:||12 Apr 2012 03:25|
|Number of Pages:||26|
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