Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16063
Papassotiropoulos, A; Stephan, D A; Huentelman, M J; Hoerndli, F J; Craig, D W; Pearson, J V; Huynh, K D; Brunner, F; Corneveaux, J; Osborne, D; Wollmer, M A; Aerni, A; Coluccia, D; Hänggi, J; Mondadori, C R A; Buchmann, A; Reiman, E M; Caselli, R J; Henke, K; de Quervain, D J F (2006). Common Kibra alleles are associated with human memory performance. Science, 314(5798):475-478.
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Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine|
04 Faculty of Medicine > Center for Integrative Human Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||20 October 2006|
|Deposited On:||18 Mar 2009 20:35|
|Last Modified:||27 Nov 2013 21:53|
|Publisher:||American Association for the Advancement of Science (AAAS)|
|Citations:||Web of Science®. Times Cited: 172|
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