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Common Kibra alleles are associated with human memory performance


Papassotiropoulos, A; Stephan, D A; Huentelman, M J; Hoerndli, F J; Craig, D W; Pearson, J V; Huynh, K D; Brunner, F; Corneveaux, J; Osborne, D; Wollmer, M A; Aerni, A; Coluccia, D; Hänggi, Jürgen; Mondadori, C R A; Buchmann, A; Reiman, E M; Caselli, R J; Henke, K; de Quervain, D J F (2006). Common Kibra alleles are associated with human memory performance. Science, 314(5798):475-478.

Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
06 Faculty of Arts > Institute of Psychology
04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:570 Life sciences; biology
150 Psychology
610 Medicine & health
Language:English
Date:20 October 2006
Deposited On:18 Mar 2009 19:35
Last Modified:04 Sep 2016 07:27
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Publisher DOI:10.1126/science.1129837
PubMed ID:17053149
Permanent URL: http://doi.org/10.5167/uzh-16063

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