Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16311
Malipiero, U; Koedel, U; Pfister, W; Fontana, A (2007). Bacterial meningitis: the role of transforming growth factor-Beta in innate immunity and secondary brain damage. Neuro-degenerative Diseases, 4(1):43-50.
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Project 6 of the NCCR 'Neural Plasticity and Repair' focuses on mechanisms of immunity and tissue damage in autoimmune and infectious diseases of the central nervous system (CNS). In one of the subprojects, the influence of transforming growth factor-beta (TGF-beta) on the immune reactivity of the CNS was investigated. In mice with Streptococcus pneumoniae-induced meningitis, a deletion of TGF-beta receptor II on leukocytes is found to enhance recruitment of neutrophils to the site of infection and to promote bacterial clearance. The improved host defense against S. pneumoniae was associated with an almost complete prevention of meningitis-induced vasculitis, a major intracranial complication leading to brain damage. The data show that endogenous TGF-beta suppresses host defense against bacterial infection in the CNS. This contrasts with findings from other body compartments that suggested that TGF-beta is a powerful chemotactic cytokine and increases microbial clearance.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology|
|DDC:||610 Medicine & health|
|Deposited On:||10 Apr 2009 15:18|
|Last Modified:||27 Nov 2013 19:52|
|Citations:||Web of Science®. Times Cited: 10|
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