Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16462
Stiefel, D; Meuli, M (2008). The dysraphic levels of skin and vertebrae are different in mouse fetuses and neonates with myelomeningocele. Journal of Pediatric Surgery, 43(4):683-690.
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BACKGROUND: Mouse fetuses with spontaneous myelomeningocele (MMC) were investigated, determining the various levels of dysraphism in soft tissue, spinal cord, and vertebrae. Morphology was correlated with hind limb function. METHODS: Viable curly tail/loop tail mouse fetuses underwent qualitative standardized ex utero examination of tail and hind limb sensitivity and motor response. Afterward, they were processed either for histology or skeletal preparation. RESULTS: All animals displayed identical cranial levels of soft tissue and neural defects. The cranial opening of the vertebral defects were invariably located more cranially (range, 0.5-5 vertebrae; mean = 2.25). The caudal opening of soft/neural tissue and bony defects was invariably at the coccygeal base. The comparison of functional with morphological levels demonstrated that, in 52.5%, the level of the soft/neural tissue dysraphism and, in 47.5%, the level of the bony opening correlated with the neurologic deficit. CONCLUSION: The naturally occurring soft tissue coverage over the MMC could exert a protective effect toward the underlying spinal cord. This interpretation supports the concept that in utero acquired destruction of exposed neural tissue is a main factor for the neonatal functional deficit. Thus, these data are consistent with the rationale for prenatal MMC repair in humans.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery|
|DDC:||610 Medicine & health|
|Deposited On:||05 Mar 2009 09:21|
|Last Modified:||27 Nov 2013 16:26|
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