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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1655

Perry, M B; MacLean, L L; Gmür, R; Wilson, M E (1996). Characterization of the O-polysaccharide structure of lipopolysaccharide from Actinobacillus actinomycetemcomitans serotype b. Infection and Immunity, 64(4):1215-1219.

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Abstract

We previously reported that the serotype b antigen of Actinobacillus actinomycetemcomitans is a constituent of the polysaccharide region of lipopolysaccharide (LPS) and contains significant amount of the neutral sugars rhamnose and fucose (M. Wilson and R. Schifferle, Infect. Immun. 59:1544-1551, 1991). In the present study, we determined the structure of the O antigen of A. actinomycetemcomitans Y4 (serotype b) LPS. Aqueous phase LPS was obtained from a phenol-water extract of A. actinomycetemcomitans Y4. This material was found to react with rabbit polyclonal antiserum to serotype b but not with antisera specific for other A. actinomycetemcomitans serotypes. Analyses revealed that the O polysaccharide of Y4 LPS consists of a polymer of trisaccharide repeating units composed of D-Fuc, AL-Rha, and D-GalNAc residues. An identical structure was obtained for the O polysaccharide of LPS from A. actinomycetemcomitans JP2, another serotype b strain. These results indicate that the serotype b antigen of A. actinomycetemcomitans is defined by a trisaccharide repeating unit present in the O polysaccharide of LPS.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
DDC:610 Medicine & health
Language:English
Date:1 April 1996
Deposited On:11 Feb 2008 12:24
Last Modified:27 Nov 2013 16:24
Publisher:American Society for Microbiology
ISSN:0019-9567
Related URLs:http://iai.asm.org/cgi/content/abstract/64/4/1215
PubMed ID:8606081
Citations:Web of Science®. Times Cited: 41
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