UZH-Logo

Maintenance Infos

Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels


Schwank, G; Restrepo, S; Basler, K (2008). Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development, 135(24):4003-4013.

Abstract

Morphogens can control organ development by regulating patterning as well as growth. Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp) regulates cell proliferation. Contrary to previous models, which implicated the slope of the Dpp gradient as an essential driver of cell proliferation, we find that the juxtaposition of cells with differential pathway activity is not required for proliferation. Additionally, our results demonstrate that, as is the case for patterning, Dpp controls wing growth entirely via repression of the target gene brinker (brk). The Dpp-Brk system converts an inherently uneven growth program, with excessive cell proliferation in lateral regions and low proliferation in medial regions, into a spatially homogeneous profile of cell divisions throughout the disc.

Morphogens can control organ development by regulating patterning as well as growth. Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp) regulates cell proliferation. Contrary to previous models, which implicated the slope of the Dpp gradient as an essential driver of cell proliferation, we find that the juxtaposition of cells with differential pathway activity is not required for proliferation. Additionally, our results demonstrate that, as is the case for patterning, Dpp controls wing growth entirely via repression of the target gene brinker (brk). The Dpp-Brk system converts an inherently uneven growth program, with excessive cell proliferation in lateral regions and low proliferation in medial regions, into a spatially homogeneous profile of cell divisions throughout the disc.

Citations

62 citations in Web of Science®
62 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

185 downloads since deposited on 02 Mar 2009
30 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:December 2008
Deposited On:02 Mar 2009 11:21
Last Modified:05 Apr 2016 13:07
Publisher:Company of Biologists
ISSN:0950-1991
Additional Information:Free full text article
Publisher DOI:10.1242/dev.025635
PubMed ID:19029041
Permanent URL: http://doi.org/10.5167/uzh-16600

Download

[img]
Preview
Filetype: PDF
Size: 3MB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations