Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16601

Affolter, M; Pyrowolakis, G; Weiss, A; Basler, K (2008). Signal-induced repression: the exception or the rule in developmental signaling? Developmental Cell, 15(1):11-22.

[img] PDF - Registered users only
2MB

Abstract

Cell-cell communication plays a key role in organ formation and patterning in multicellular animals and is carried out by a few evolutionarily conserved signaling pathways. The modes of action of these pathways share a number of general properties, or habits, that allow them to strongly activate target genes in a ligand-dependent manner in the proper cellular contexts. Recent studies have revealed that some developmental signaling pathways can also strongly repress genes in a ligand-dependent manner. These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:July 2008
Deposited On:02 Mar 2009 18:17
Last Modified:27 Nov 2013 23:40
Publisher:Elsevier
ISSN:1534-5807
Publisher DOI:10.1016/j.devcel.2008.06.006
PubMed ID:18606137
Citations:Web of Science®. Times Cited: 12
Google Scholar™
Scopus®. Citation Count: 14

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page