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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16630

Jayawardane, G; Russel, G C; Thomson , J; Deane , D; Cox, H; Gatherer, D; Ackermann, M; Haig, D M; Stewart, J P (2008). A captured viral interleukin 10 gene with cellular exon structure. Journal of General Virology, 89(10):2447-2455.

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We have characterized a novel, captured and fully functional viral interleukin (IL)-10 homologue (OvHVIL-10) from the gammaherpesvirus ovine herpesvirus 2. Unlike IL-10 homologues from other gammaherpesviruses, the OvHVIL-10 peptide sequence was highly divergent from that of the host
species. The OvHVIL-10 gene is unique amongst virus captured genes in that it has precisely retained the original cellular exon structure, having five exons of similar sizes to the cellular counterparts. However, the sizes of the introns are dramatically reduced. The OvHVIL-10 protein
was shown to be a non-glycosylated, secreted protein of Mr 21 000 with a signal peptidase cleavage site between amino acids 26 and 27 of the nascent peptide. Functional assays showed that OvHVIL-10, in a similar way to ovine IL-10, stimulated mast cell proliferation and inhibited macrophage inflammatory chemokine production. This is the first example of a captured herpesvirus gene retaining the full cellular gene structure.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
DDC:570 Life sciences; biology
Deposited On:25 Feb 2009 13:52
Last Modified:16 Jan 2014 00:49
Publisher:Society for General Microbiology
Publisher DOI:10.1099/vir.0.2008/001743-0
Citations:Web of Science®. Times Cited: 15
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Scopus®. Citation Count: 15

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