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Stoeckli, E T (1997). Molecular mechanisms of growth cone guidance: stop and go? Cell and Tissue Research, 290(2):441-449.

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Evidence from pathfinding studies in both vertebrates and invertebrates indicates that growth cones are not guided by simple stop or go signals. Rather, the navigation of growth cones through the preexisting tissue is controlled by a continuous integration of both positive and negative cues. The path taken by an axon is determined by the continuously changing situation encountered by the growth cone at any given site along the trajectory of the axon to the target. The signals derived from interactions of surface molecules with these cues provided by the environment of the growth cone are constantly changing both temporally and spatially. Therefore, each growth cone encounters a unique set of guidance cues directing it to its specific target, thus allowing for the tremendous complexity required for the guidance of millions of axons in the developing nervous system.


10 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:1 November 1997
Deposited On:11 Feb 2008 12:13
Last Modified:27 Nov 2013 22:19
Publisher DOI:10.1007/s004410050951
Related URLs:http://www.springerlink.com/(mxacvpmyskfloqq0c2epsuug)/app/home/contribution.asp?referrer=parent&backto=issue,32,35;journal,108,1221;linkingpublicationresults,1:100524,1
PubMed ID:9321708

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