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Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues


Münz, C (2008). Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues. European Journal of Immunology, 38(11):2946-2948.

Abstract

Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56brightCD16(-) NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.

Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56brightCD16(-) NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.

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12 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2008
Deposited On:11 Jan 2010 13:13
Last Modified:05 Apr 2016 13:07
Publisher:Wiley-Blackwell
ISSN:0014-2980
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:10.1002/eji.200838849
PubMed ID:18979517
Permanent URL: http://doi.org/10.5167/uzh-16724

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