Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16726
Münz, C; Moormann, A (2008). Immune escape by Epstein-Barr virus associated malignancies. Seminars in Cancer Biology, 18(6):381-387.
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Persistent Epstein-Barr virus (EBV) infection remains asymptomatic in the majority of virus carriers, despite the potent growth transforming potential of this virus. The increased frequency of EBV associated B cell lymphomas in immune compromised individuals suggests that tumor-free chronic infection with this virus is in part due to immune control. Here we discuss the evidence that loss of selective components of EBV specific immunity might contribute to EBV associated malignancies, like nasopharyngeal carcinoma, Burkitt's and Hodgkin's lymphoma, in otherwise immune competent patients. Furthermore, we discuss how current vaccine approaches against EBV might be able to target these selective deficiencies.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > Institute of Experimental Immunology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||11 Jan 2010 13:23|
|Last Modified:||27 Nov 2013 21:30|
|Free access at:||Publisher DOI. An embargo period may apply.|
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