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Müller, J; Sigel, R K O; Lippert, B (2000). Heavy metal mutagenicity: insights from bioinorganic model chemistry. Journal of Inorganic Biochemistry, 79(1-4):261-265.

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Abstract

The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered.

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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Department of Chemistry
DDC:540 Chemistry
Language:English
Date:1 April 2000
Deposited On:11 Feb 2008 12:24
Last Modified:27 Nov 2013 19:27
Publisher:Elsevier
ISSN:0162-0134
Publisher DOI:10.1016/S0162-0134(99)00179-8
PubMed ID:10830876

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