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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-16939

van Werkhoven, J M; Schuijf, J D; Gaemperli, O; Jukema, J W; Boersma, E; Wijns, W; Stolzmann, P; Alkadhi, H; Valenta, I; Stokkel, M P M; Kroft, L J; de Roos, A; Pundziute, G; Scholte, A; van der Wall, E E; Kaufmann, P A; Bax, J J (2009). Prognostic value of multislice computed tomography and gated single-photon emission computed tomography in patients with suspected coronary artery disease. Journal of the American College of Cardiology, 53(7):623-632.

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Abstract

OBJECTIVES: This study was designed to determine whether multislice computed tomography (MSCT) coronary angiography has incremental prognostic value over single-photon emission computed tomography myocardial perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD). BACKGROUND: Although MSCT is used for the detection of CAD in addition to MPI, its incremental prognostic value is unclear. METHODS: In 541 patients (59% male, age 59 +/- 11 years) referred for further cardiac evaluation, both MSCT and MPI were performed. The following events were recorded: all-cause death, nonfatal infarction, and unstable angina requiring revascularization. RESULTS: In the 517 (96%) patients with an interpretable MSCT, significant CAD (MSCT > or =50% stenosis) was detected in 158 (31%) patients, and abnormal perfusion (summed stress score [SSS]: > or =4) was observed in 168 (33%) patients. During follow-up (median 672 days; 25th, 75th percentile: 420, 896), an event occurred in 23 (5.2%) patients. After correction for baseline characteristics in a multivariate model, MSCT emerged as an independent predictor of events with an incremental prognostic value to MPI. The annualized hard event rate (all-cause mortality and nonfatal infarction) in patients with none or mild CAD (MSCT <50% stenosis) was 1.8% versus 4.8% in patients with significant CAD (MSCT > or =50% stenosis). A normal MPI (SSS <4) and abnormal MPI (SSS > or =4) were associated with an annualized hard event rate of 1.1% and 3.8%, respectively. Both MSCT and MPI were synergistic, and combined use resulted in significantly improved prediction (log-rank test p value <0.005). CONCLUSIONS: MSCT is an independent predictor of events and provides incremental prognostic value to MPI. Combined anatomical and functional assessment may allow improved risk stratification.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:12 Mar 2009 11:24
Last Modified:27 Nov 2013 22:30
Publisher:Elsevier
ISSN:0735-1097
Publisher DOI:10.1016/j.jacc.2008.10.043
PubMed ID:19215839
Citations:Web of Science®. Times Cited: 144
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